26 articles - From Saturday Apr 16 2022 to Friday Apr 22 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Arthritis Care Res (Hoboken) |
Imaging features of calcium pyrophosphate deposition (CPPD) disease: consensus definitions from an international multidisciplinary working group. An international group of rheumatologists and musculoskeletal radiologists defined imaging features characteristic of CPPD on CR, CT, and DECT, and assembled a set of example images as a reference for future clinical research studies. |
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Low-ratio somatic NLRC4 mutation causes late-onset autoinflammatory disease. We used single-cell RNA sequencing (scRNA-seq), intracellular cytokine staining, quantitative PCR, immunohistochemistry and western blotting to define inflammatory signatures and to explore the pathogenic mechanism. Results We identified a somatic mutation in mutation in a small subset of leucocytes. We systemically analysed this condition at a single-cell transcriptomic level and revealed specific enhancement of inflammatory response in myeloid cells. |
| Arthritis Care Res (Hoboken) |
Cost-effectiveness of the early arthritis clinic organizational model: the ELECTRA study. Despite an expected increase in outpatient costs (visits and diagnostic tests) and pharmaceutical costs, the reduction in terms of number and length of hospitalizations and the higher adherence to international quality of care guidelines support the effectiveness of the EAC model. |
Predictors of Thirty-Day Hospital Readmissions in Systemic Lupus Erythematosus in the US: A Nationwide Study. In this nationally representative study of SLE readmissions, the strongest risk factors for 30-day readmission were younger age, SLE-related manifestations, and public insurance. These results identify patient groups with SLE that would benefit from post-discharge interventions designed to reduce hospitalizations and improve health outcomes. |
| Arthritis Res Ther |
Impact of serum interleukin-22 as a biomarker for the differential use of molecular targeted drugs in psoriatic arthritis: a retrospective study. The results of this pilot study suggest that IL-22 may be a biomarker of treatment response to TNF-i and IL-17-i in patients with PsA. Further large-scale studies in independent, prospectively collected datasets are required to verify that IL-22 is indeed a biomarker of treatment response in these patients. |
One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study. In patients with gout, flares remain frequent during the first year of a treat-to-target ULT strategy, especially during months 3-6, but are much less frequent during year 2. Baseline crystal depositions predict flares over 2 |
| Arthritis Rheumatol |
IL-13Ra1-Mediated Signaling Regulates Age-Associated/Autoimmune B-Cell Expansion and Lupus Pathogenesis. These studies uncover a novel role for IL-13Ra1 in the control of ABC generation and differentiation suggesting that IL-13Ra1 contributes to these effects by regulating a subset of IL-21-mediated signaling events. These studies also suggest that X-linked genes besides TLR7 participate in the regulation of ABCs in lupus. |
Progressive increase in sacroiliac joint and spinal mri lesions in healthy individuals in relation to age. Contrary to what is commonly believed, structural MRI-SIJ lesions are frequently seen in healthy individuals. Especially in older subjects, the high occurrence of inflammatory and structural MRI lesions impacts their specificity for SpA, which has important implications for the interpretation of MRI in patients with clinical suspicion of SpA. |
Treatment with Tumour Necrosis Factor Inhibitors is Associated with a Time-Shifted Retardation of Radiographic Sacroiliitis Progression in Patients with Axial Spondyloarthritis: 10-year Results from the German Spondyloarthritis Inception Cohort. TNFi was associated with reduction of radiographic sacroiliitis progression in patients with axSpA. This effect became evident between 2 and 4 |
| Rheumatology (Oxford) |
Cytokine profile, ferritin, and multi-visceral involvement characterise macrophage activation syndrome during adult-onset Still's disease. A multidimensional characterisation of AOSD patients suggested that IFN- |
Development and validation of the Kids Disability Screen for children with juvenile idiopathic arthritis: results from the CAPRI Registry. This simple KDS has psychometric properties comparable to a full CHAQ and may be used at every clinic visit to identify children who need a full disability assessment. |
Exploring discordance between Health Literacy Questionnaire scores of people with RMDs and assessment by treating health professionals. Frequent discordance between patients' scores and professionals' estimations indicates there may be hidden challenges in communication and care, which differ between socioeconomic groups. Successfully addressing patients' health literacy needs cannot solely depend on health professionals' estimations but will require measurement and dialogue. |
The effect of silver fibre gloves on Raynaud's phenomenon in patients with systemic sclerosis: a double-blind randomized cross-over trial. Wearing gloves in SSc patients clearly decreases the RP burden. Our results do not support the hypothesis that increased heat transport of 8%-silver fibre gloves is associated with less disease burden as measured in this study by RCS compared with normal gloves. Clinical trial registration |
Whole blood drug levels do not correlate with QTc intervals in hydroxychloroquine treated systemic lupus erythematosus patients. This is the first study relying on measured blood levels demonstrating the absence of clinically consequential increase in QTc levels in HCQ treated SLE patients. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Care Res (Hoboken) |
Impact of belimumab on organ damage in systemic lupus erythematosus. Long-term belimumab use in SLE also reduced organ damage progression measured by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), as reported in open-label extension studies, and propensity score-matched comparative analyses to background therapy alone. Results from a clinical trial showed that in patients with active LN, belimumab treatment improved renal response, reduced the risk of renal-related events and impacted features related to kidney damage progression, compared with background therapy alone. The decrease of organ damage accumulation observed with belimumab treatment in SLE, including LN, suggest a disease-modifying effect. |
| Arthritis Rheumatol |
Letters to the editors and authors’ replies
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…
| Rheumatology (Oxford) |